Advancing Bioinformatics, Translational Bioinformatics and Computational Biology Research (R01 Clinical Trial Optional)
About
The National Library of Medicine (NLM) seeks applications for research projects that drive groundbreaking innovation and advanced development in the fields of bioinformatics, translational bioinformatics, and computational biology. The primary goal of this initiative is to support the creation and implementation of cutting-edge methods, tools, and approaches that can transform the landscape of biomedical data science. This NOFO aims to address the growing need to leverage transformative technologies — such as artificial intelligence (AI), machine learning, and large-scale computational platforms — to extract actionable knowledge from vast, diverse, and complex biological datasets. By enabling more effective interpretation and integration of multi-dimensional biological and biomedical data, this research will ultimately contribute to improving individual and population health outcomes.
The Advancing Bioinformatics, Translational Bioinformatics and Computational Biology Research (R01 Clinical Trial Optional) grant program, administered by the National Library of Medicine (NLM), is designed for researchers and organizations pursuing innovative projects in bioinformatics, translational bioinformatics, and computational biology. This program funds the development and implementation of cutting-edge methods, tools, and computational approaches that transform biomedical data science and improve health outcomes. The initiative specifically supports research leveraging artificial intelligence, machine learning, and large-scale computational platforms to extract actionable insights from complex biological datasets. Eligible applicants include U.S.-based research institutions, academic centers, and qualifying organizations, with provisions for international collaborations and non-domestic components. Researchers should apply if their work focuses on advancing computational biology methodologies, developing novel bioinformatics solutions, or implementing translational approaches that bridge laboratory discoveries and clinical applications. This grant opportunity is ideal for teams seeking substantial federal funding to support multi-year research projects that address critical gaps in biomedical data interpretation and integration across diverse biological systems.
Funding Facts
● Applications openDeadline
March 5, 2029
Award Amount
Up to $250K
Who can apply
Last verified July 5, 2026 · Source: Grants.gov
Grant Details
Grant Amount
Up to $250K
Deadline
2029-03-05
Grant Type
federal
Application Cycle
Annual
Best For
Research institutions, academic centers, and organizations advancing bioinformatics, computational biology, and translational bioinformatics research
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no l
Frequently Asked Questions
Who is eligible for Advancing Bioinformatics, Translational Bioinformatics and Computational Biology Research (R01 Clinical Trial Optional)?
Eligible applicants include domestic U.S. organizations and entities. Foreign organizations and non-domestic components of U.S. organizations may also apply, and foreign components are permitted as defined in the NIH Grants Policy Statement. For complete eligibility requirements, including institutional qualifications and researcher credentials, refer to Section III of the Notice of Funding Opportunity (NOFO) on the official NLM website.
How much funding does Advancing Bioinformatics, Translational Bioinformatics and Computational Biology Research (R01 Clinical Trial Optional) provide?
Funding ranges up to $250,000. The specific amount available may vary depending on the funding cycle and individual project scope. Applicants should consult the current NOFO for detailed budget guidelines and any updates to funding levels.
How do I apply for Advancing Bioinformatics, Translational Bioinformatics and Computational Biology Research (R01 Clinical Trial Optional)?
Applications are submitted through the NIH grants portal in accordance with the specific guidelines outlined in the NOFO. The deadline for applications is March 5, 2029. Applicants should review the complete NOFO on the National Library of Medicine or NIH website for detailed submission instructions, required forms, and specific application procedures.
What can Advancing Bioinformatics, Translational Bioinformatics and Computational Biology Research (R01 Clinical Trial Optional) funding be used for?
Funding supports research projects focused on developing and implementing innovative methods, tools, and approaches in bioinformatics, translational bioinformatics, and computational biology. This includes research utilizing artificial intelligence and machine learning to analyze complex biological datasets, creation of computational platforms for biomedical data integration, and projects aimed at improving the interpretation of multi-dimensional biological data to enhance health outcomes.
Last updated: July 5, 2026