Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions (U01 Clinical Trial Not Allowed)
About
This Notice of Funding Opportunity (NOFO) invites applications for innovative research on the factors that cause human behaviors and the oral-systemic health impacts of those behaviors to enhance health, lengthen life, and reduce illness and disability among people with chronic conditions. Causal hypotheses may include biological, biopsychosocial, congenital, environmental, interpersonal, neurological, psychological, and comorbidity factors that individually, sequentially, or in combination trigger human behaviors and oral-systemic health outcomes, with impacts that may be direct or traceably distal. Applications that propose projects to develop or refine causal hypotheses also are encouraged.
This Notice of Funding Opportunity (NOFO) supports innovative research investigating the causal factors behind human behaviors and their oral-systemic health impacts among people with chronic conditions. Researchers are invited to develop and test causal hypotheses examining biological, biopsychosocial, congenital, environmental, interpersonal, neurological, psychological, and comorbidity factors that trigger behaviors and oral-systemic health outcomes. This grant is ideal for research institutions, universities, and eligible organizations seeking to advance understanding of how behavioral patterns affect both oral and overall health in chronic disease populations. The program encourages applications proposing projects that develop, refine, or validate causal hypotheses about these interconnected health relationships. By funding this research, the program aims to enhance health outcomes, extend life expectancy, and reduce illness and disability among individuals living with chronic conditions. Researchers should note that clinical trial projects are not eligible under this funding mechanism. This opportunity represents a significant investment in understanding the behavioral determinants of health disparities and the complex relationships between oral health and systemic disease management.
Funding Facts
● Applications openDeadline
July 5, 2029
Award Amount
Up to $500K
Who can apply
Last verified July 29, 2026 · Source: Grants.gov
Grant Details
Grant Type
federal
Best For
Research institutions, universities, and eligible domestic organizations conducting mechanistic and behavioral health research
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Frequently Asked Questions
Who is eligible for Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions (U01 Clinical Trial Not Allowed)?
Domestic U.S. organizations and entities are eligible to apply. Foreign organizations, non-domestic components of U.S. organizations, and foreign components as defined in the NIH Grants Policy Statement are not eligible. For complete eligibility details, refer to Section III of the Notice of Funding Opportunity or visit the official NIH website.
How much funding does Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions (U01 Clinical Trial Not Allowed) provide?
Funding ranges from up to $500,000. The specific amount awarded may vary based on the scope and merit of individual projects. Consult the official NOFO for details on budget guidelines and funding cycles.
How do I apply for Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions (U01 Clinical Trial Not Allowed)?
Submit your application through the official NIH grants portal (Grants.gov). Ensure your proposal aligns with the NOFO requirements and includes a strong causal hypothesis framework. Review the complete NOFO document for submission guidelines, required documentation, and specific instructions. The application deadline is July 5, 2029.
What can Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions (U01 Clinical Trial Not Allowed) funding be used for?
Funding supports research that develops or refines causal hypotheses about the factors triggering human behaviors and oral-systemic health outcomes in chronic disease populations. Projects may examine biological, psychological, environmental, neurological, and other mechanistic factors. Note that clinical trial projects are not eligible under this mechanism. Funds support research infrastructure, personnel, and investigative costs aligned with the proposed causal hypothesis research.
Last updated: July 29, 2026