Data Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative U24 Clinical Trial Required)
About
This Notice of Funding Opportunity (NOFO) supports applications for a collaborating Data Coordinating Center (DCC) for investigator-initiated multi-site clinical trials including efficacy, comparative effectiveness, pragmatic and/or implementation research clinical trials. Trials using innovative designs such as platform trials, adaptive, and Bayesian designs are encouraged. These trials may include ones that test different therapeutic, behavioral, and/or prevention strategies. Trials for which this NOFO applies must be relevant to the research mission of the NHLBI and meet the NIH definition of a clinical trial (see NOT-OD-15-015). For additional information about the mission, strategic vision, and research priorities of the NHLBI, applicants are encouraged to consult the NHLBI website. This NOFO will utilize a milestone-driven cooperative agreement mechanism of award and runs in parallel with a companion NOFO (PAR-27-012) for a collaborating Clinical Coordinating Center (CCC). The objective of the DCC application is to present a comprehensive plan to provide overall project coordination, administration, data management, and biostatistical support for the clinical trial proposed in the collaborating CCC application. The application should also describe its approaches to collaborate with the CCC on implementation of the clinical trial community engagement plan. Both a DCC application and a collaborating CCC application must be submitted on the same application due date for con.
The Data Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative U24 Clinical Trial Required) is a federal funding opportunity designed to support research institutions and organizations conducting multi-site clinical trials aligned with the National Heart, Lung, and Blood Institute (NHLBI) research mission. This grant funds the establishment of a Data Coordinating Center (DCC) that provides comprehensive project coordination, administration, data management, and biostatistical support for investigator-initiated clinical trials. Eligible trials include efficacy studies, comparative effectiveness research, pragmatic trials, and implementation science research testing therapeutic, behavioral, and prevention strategies. The program particularly encourages innovative trial designs such as platform trials, adaptive designs, and Bayesian methodologies. Applicants must submit a DCC application in parallel with a companion Clinical Coordinating Center (CCC) application on the same due date. This opportunity is ideal for research organizations with strong data management and biostatistical capabilities seeking to lead critical multi-site clinical research efforts. Both domestic U.S. organizations and foreign entities are eligible to apply, making this a broadly accessible funding mechanism for advancing clinical trial infrastructure and research coordination.
Funding Facts
● Applications openDeadline
November 2, 2028
Who can apply
Last verified July 5, 2026 · Source: Grants.gov
Grant Details
Funding Range
Varies by cycle - consult official NOFO
Deadline
2028-11-02
Grant Type
federal
Application Cycle
Annual cycle (Next deadline: November 2, 2028)
Best For
Research institutions, academic medical centers, and organizations with expertise in data management, biostatistics, and multi-site clinical trial coordination
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer
Frequently Asked Questions
Who is eligible for Data Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative U24 Clinical Trial Required)?
Eligible applicants include U.S. domestic organizations and foreign organizations. Non-domestic (non-U.S.) entities and foreign components of U.S. organizations may apply. For complete eligibility requirements, refer to Section III of the Notice of Funding Opportunity (NOFO) on the official NIH/NHLBI website.
How much funding does Data Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative U24 Clinical Trial Required) provide?
The specific funding amounts are not specified in this funding cycle announcement. Award amounts may vary depending on the scope and complexity of the proposed clinical trial's data coordination needs. Contact the NHLBI directly or consult the official NOFO for current funding details and budget guidelines.
How do I apply for Data Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative U24 Clinical Trial Required)?
Applications must be submitted through the NIH grants submission system. Importantly, a DCC application must be submitted in parallel with a companion Clinical Coordinating Center (CCC) application on the same application due date. Both applications are required for consideration. Visit the official NIH NHLBI website and consult the complete NOFO (PAR-27-012) for detailed application instructions, formatting requirements, and submission guidelines.
What can Data Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative U24 Clinical Trial Required) funding be used for?
Funding supports establishing a Data Coordinating Center to provide: overall project coordination and administration, data management systems and infrastructure, biostatistical support and analysis, and collaboration with the Clinical Coordinating Center on implementing the clinical trial community engagement plan. The DCC serves as the central data and administrative hub for multi-site investigator-initiated clinical trials relevant to NHLBI's research mission.
Last updated: July 5, 2026