Development and Testing of Novel Interventions to Improve HIV Prevention, Treatment, and Program Implementation for People Who Use Substances (R34 Clinical Trial Required)
About
This notice of funding opportunity (NOFO) encourages formative research, intervention development, and pilot-testing of interventions. Primary scientific areas of focus include the feasibility, tolerability, acceptability and safety of novel or adapted interventions that target HIV prevention, treatment or services research for people who use drugs. For the purposes of this NOFO, "intervention" may include behavioral, social, or structural approaches, as well as combination biomedical and behavioral approaches that prevent the acquisition and transmission of HIV infection, or improve clinical outcomes for persons living with HIV.
The Development and Testing of Novel Interventions to Improve HIV Prevention, Treatment, and Program Implementation for People Who Use Substances (R34 Clinical Trial Required) grant supports researchers and organizations developing innovative approaches to address HIV among people who use drugs. This funding opportunity prioritizes formative research, intervention development, and pilot-testing of new or adapted interventions that demonstrate feasibility, tolerability, acceptability, and safety. Eligible interventions encompass behavioral, social, and structural approaches, as well as combination biomedical and behavioral strategies that prevent HIV acquisition and transmission or improve clinical outcomes for people living with HIV. Researchers, academic institutions, faith-based organizations, community-based organizations, and tribal governments are encouraged to apply. This grant is ideal for organizations seeking to test groundbreaking solutions that address gaps in HIV prevention and treatment services for vulnerable populations. By supporting evidence-based intervention development, this opportunity drives meaningful progress in public health and community health outcomes. Applicants should visit the official funding agency website for the most current eligibility requirements, application procedures, and specific funding amounts for the current funding cycle.
Funding Facts
● Applications openDeadline
March 16, 2027
Who can apply
Last verified July 5, 2026 · Source: Grants.gov
Grant Details
Funding Range
Varies by funding cycle
Deadline
2027-03-16
Grant Type
federal
Application Cycle
Annual deadline; consult official NOFO for current cycle dates
Best For
Research institutions, HBCUs, community-based organizations, tribal governments, and faith-based organizations developing HIV interventions for people who use substances
Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Govern
Frequently Asked Questions
Who is eligible for Development and Testing of Novel Interventions to Improve HIV Prevention, Treatment, and Program Implementation for People Who Use Substances (R34 Clinical Trial Required)?
Eligible applicants include Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Alaska Native and Native Hawaiian Serving Institutions, Indian/Native American Tribal Governments, Faith-based or Community-based Organizations, and Eligible Agencies of the Federal Government. For a complete and current list of eligibility criteria, visit the official funding agency website.
How much funding does Development and Testing of Novel Interventions to Improve HIV Prevention, Treatment, and Program Implementation for People Who Use Substances (R34 Clinical Trial Required) provide?
Specific funding amounts vary by funding cycle. Please consult the official Notice of Funding Opportunity (NOFO) on the funding agency's website for current award ranges and budget details.
How do I apply for Development and Testing of Novel Interventions to Improve HIV Prevention, Treatment, and Program Implementation for People Who Use Substances (R34 Clinical Trial Required)?
Applications are submitted through the official federal grants portal. The application typically requires a detailed research proposal, budget narrative, organizational capacity documentation, and evidence of feasibility for your proposed intervention. Visit the official funding agency website to access the complete NOFO, submission guidelines, required forms, and the application deadline.
What can Development and Testing of Novel Interventions to Improve HIV Prevention, Treatment, and Program Implementation for People Who Use Substances (R34 Clinical Trial Required) funding be used for?
Funding supports formative research, intervention development, and pilot-testing of novel or adapted interventions targeting HIV prevention, treatment, and services for people who use drugs. This includes behavioral, social, structural, and combination biomedical-behavioral approaches. Funds may support research staff, participant recruitment and retention, intervention delivery, data collection, and feasibility/tolerability/acceptability/safety assessments.
Last updated: July 5, 2026