Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R33 Clinical Trial Required)
About
Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R33 Clinical Trial Required). As part of NIMH's clinical trials pipeline, this NOFO encourages pilot research developing and testing novel psychosocial interventions and/or targets. Consistent with NIMH's emphasis on the experimental therapeutics approach to intervention development, it intends to speed the translation of emergent research in basic, behavioral, cognitive, affect, and neuropsychological science into preventative or therapeutic interventions. This RFA will provide up to three years of support to replicate target engagement from prior studies and to test the association between target engagement and change in clinical outcome(s).
The Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R33 Clinical Trial Required) grant is designed for researchers and organizations developing innovative psychosocial interventions to treat and prevent mental health disorders. Funded by the National Institute of Mental Health (NIMH), this program supports the translation of cutting-edge research from basic, behavioral, cognitive, affect, and neuropsychological sciences into practical therapeutic and preventive interventions. This grant is ideal for research institutions, universities, behavioral health organizations, and eligible community-based entities committed to advancing mental health treatment. The R33 mechanism specifically requires clinical trial components, making it suitable for researchers ready to move beyond pilot studies into rigorous testing phases. Applicants can receive up to three years of funding to replicate target engagement findings from prior research and demonstrate the connection between target engagement and measurable clinical outcomes. If your organization is developing novel psychosocial approaches aligned with NIMH's experimental therapeutics framework, this grant offers a pathway to advance your work and contribute to the nation's mental health innovation pipeline.
Funding Facts
● Applications openDeadline
October 15, 2027
Who can apply
Last verified July 5, 2026 · Source: Grants.gov
Grant Details
Funding Range
Up to three years of support (specific amounts vary by cycle)
Deadline
2027-10-15
Grant Type
federal
Application Cycle
Annual (Deadline: October 15, 2027)
Best For
Research institutions, universities, HBCUs, minority-serving institutions, and community-based organizations developing psychosocial mental health interventions
Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Govern
Frequently Asked Questions
Who is eligible for Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R33 Clinical Trial Required)?
Eligible applicants include Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Alaska Native and Native Hawaiian Serving Institutions, faith-based and community-based organizations, and eligible federal government agencies. For a complete and current list of eligibility requirements, visit the official NIMH Notice of Funding Opportunity (NOFO) on the NIH website.
How much funding does Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R33 Clinical Trial Required) provide?
Funding amounts vary by cycle and specific project needs. The grant provides support for up to three years of research. For current funding ranges and budget guidelines, consult the official NOFO on the NIH grants website.
How do I apply for Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R33 Clinical Trial Required)?
Applications are submitted through the NIH electronic application system (eRA Commons/Grants.gov). Applicants must prepare a detailed research proposal that includes clinical trial plans, target engagement replication strategies, and outcome measurement approaches. The next deadline is October 15, 2027. For detailed submission instructions and application requirements, visit the official NIMH NOFO or contact your institution's grants office.
What can Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R33 Clinical Trial Required) funding be used for?
Funding supports the development and testing of novel psychosocial interventions and therapeutic targets. Specifically, it funds replication of target engagement from prior studies and testing the association between target engagement and clinical outcomes. Acceptable uses include research personnel, clinical trial implementation, participant assessments, data analysis, and other direct costs aligned with intervention development and evaluation research.
Last updated: July 5, 2026