Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R61/R33 Clinical Trial Required)
About
Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R61/R33 Clinical Trial Required). As part of NIMH's clinical trials pipeline, this NOFO encourages pilot research developing and testing novel psychosocial interventions and/or targets. Consistent with NIMH's emphasis on the experimental therapeutics approach to intervention development, it intends to speed the translation of emergent research in basic, behavioral, cognitive, affect, and neuropsychological science into preventative or therapeutic interventions. This RFA will provide up to two years of support for evaluation of target engagement and establishment of intervention parameters, and up to three years of support to replicate target engagement from prior studies and to test the association between target engagement and change in clinical outcome(s).
The Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R61/R33 Clinical Trial Required) grant program is designed for researchers and organizations seeking to advance mental health treatment and prevention through innovative psychosocial interventions. This National Institute of Mental Health (NIMH) funding opportunity supports the development and testing of novel therapeutic approaches grounded in basic, behavioral, cognitive, affect, and neuropsychological science. The program emphasizes an experimental therapeutics approach, accelerating the translation of emerging research into practical interventions for mental disorders. Eligible applicants include HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, faith-based and community-based organizations, and other qualified entities. The two-phase structure provides initial funding for pilot research and target engagement evaluation, followed by additional support for replication studies and clinical outcome testing. Researchers and organizations developing cutting-edge mental health interventions should apply to access substantial federal funding and contribute to NIMH's clinical trials pipeline, ultimately improving mental health outcomes nationwide.
Funding Facts
● Applications openDeadline
October 15, 2027
Who can apply
Last verified July 5, 2026 · Source: Grants.gov
Grant Details
Funding Range
Varies by project phase and scope
Deadline
2027-10-15
Grant Type
federal
Application Cycle
Annual (Next deadline: October 15, 2027)
Best For
Research institutions, universities, HBCUs, minority-serving institutions, community-based organizations developing novel mental health interventions
Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Govern
Frequently Asked Questions
Who is eligible for Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R61/R33 Clinical Trial Required)?
Eligible applicants include Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), faith-based and community-based organizations, eligible federal agencies, and other qualified research institutions. For a complete list of eligible applicants and specific requirements, visit the official NIMH funding announcement on Grants.gov.
How much funding does Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R61/R33 Clinical Trial Required) provide?
Specific funding amounts vary by cycle and project scope. The program typically supports up to two years for initial pilot research and target engagement evaluation, and up to three years for replication and clinical outcome testing phases. For current funding ranges and budget details, consult the official NOFO (Notice of Funding Opportunity) on the NIH website.
How do I apply for Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R61/R33 Clinical Trial Required)?
Applications are submitted through Grants.gov and the NIH eRA Commons system. The next deadline is October 15, 2027. Applicants should prepare a detailed research proposal describing their novel psychosocial intervention, target engagement metrics, and clinical trial design. Visit the official NIMH website and the specific NOFO for complete application instructions, required forms, and submission guidelines.
What can Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R61/R33 Clinical Trial Required) funding be used for?
Funding supports the development and testing of novel psychosocial therapeutic and preventive interventions for mental disorders. Allowable uses include pilot research, evaluation of target engagement, establishment of intervention parameters, replication studies, and testing associations between target engagement and clinical outcomes. All funded work must align with NIMH's experimental therapeutics approach and clinical trials pipeline priorities.
Last updated: July 5, 2026