Discovery of the Genetic Basis of Childhood Cancers and of Congenital Anomalies: Gabriella Miller Kids First Pediatric Research Program (X01 Clinical Trial Not Allowed)
About
As part of the Gabriella Miller Kids First Pediatric Research Program (Kids First Program), the NIH invites applications to submit samples from pediatric cohorts for whole genome sequencing at a Kids First Program supported genomic data generating centers. Applicants are encouraged to propose sequencing of existing pediatric cancer or congenital anomaly cohorts to elucidate the genetic contribution (somatic and/or germline) to childhood cancers, to investigate the genetic etiology of congenital anomalies, to study the molecular basis of the associations between congenital anomalies and increased cancer risk, or to expand the range of pediatric disorders included within the Kids First Data Resource. The program will accept applications that propose whole genome, exome, and transcriptome sequencing, as well as clinical-grade sequencing, long-read sequencing, proteomics, and epigenomic assays of tumor or affected tissue, when justified. Applicants are encouraged to propose cohorts to increase representation of existing Kids First Program projects. These data, and associated clinical and phenotypic data, will become part of the Kids First Data Resource Center for sharing with the research community.
The Gabriella Miller Kids First Pediatric Research Program (Kids First Program) invites researchers and institutions to submit pediatric cohort samples for comprehensive genomic sequencing and advanced molecular analysis. This NIH-supported initiative is designed for researchers studying the genetic basis of childhood cancers and congenital anomalies. Applicants can propose whole genome sequencing, exome sequencing, transcriptome sequencing, clinical-grade sequencing, long-read sequencing, proteomics, and epigenomic assays of tumor or affected tissue. The program welcomes applications examining somatic and germline genetic contributions to pediatric cancers, genetic causes of congenital anomalies, molecular associations between congenital anomalies and cancer risk, and expansion of pediatric disorders in the Kids First Data Resource. Researchers are encouraged to propose cohorts that increase representation in existing Kids First projects. All generated data and associated clinical and phenotypic information become part of the Kids First Data Resource Center, enabling broad sharing with the research community. This program is ideal for academic medical centers, research institutions, and healthcare organizations with existing pediatric cancer or congenital anomaly cohorts seeking to unlock genetic insights and contribute to pediatric medicine advancement.
Funding Facts
● Applications openDeadline
January 11, 2027
Who can apply
Last verified July 5, 2026 · Source: Grants.gov
Grant Details
Funding Range
Varies by funding cycle
Deadline
2027-01-11
Grant Type
federal
Application Cycle
Annual deadline (January 11, 2027)
Best For
Research institutions, academic medical centers, and organizations with existing pediatric cancer or congenital anomaly cohorts
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Frequently Asked Questions
Who is eligible for the Gabriella Miller Kids First Pediatric Research Program (X01 Clinical Trial Not Allowed)?
U.S. domestic entities and organizations are eligible to apply. Foreign organizations, non-domestic components of U.S. organizations, and foreign collaborations are not eligible. Clinical trial applications (X01 mechanism) are not allowed. For complete eligibility requirements, refer to Section III of the Notice of Funding Opportunity (NOFO) on the official NIH website.
How much funding does the Gabriella Miller Kids First Pediatric Research Program provide?
Specific funding amounts are not specified in the available program information and vary by funding cycle. Contact the NIH directly or visit the official NOFO for current funding details and budget information.
How do I apply for the Gabriella Miller Kids First Pediatric Research Program?
Applications must be submitted through the standard NIH grants application process. Applicants should propose sequencing and analysis of existing pediatric cancer or congenital anomaly cohorts. Detailed application instructions, required documentation, and submission procedures are available on the NIH website and in the official NOFO. The application deadline is January 11, 2027.
What can Gabriella Miller Kids First Pediatric Research Program funding be used for?
Funding supports whole genome sequencing, exome sequencing, transcriptome sequencing, clinical-grade sequencing, long-read sequencing, proteomics, and epigenomic assays of tumor or affected tissue from pediatric cohorts. The program funds research investigating genetic contributions to childhood cancers, genetic causes of congenital anomalies, molecular associations between these conditions, and expansion of pediatric disorder representation in the Kids First Data Resource.
Last updated: July 5, 2026