GREGoRi Innovation Projects (U01 Clinical Trial Optional)
About
The Genomics Research to Elucidate the Genetics of Rare Diseases: innovation (GREGoRi) initiative seeks to accelerate a paradigm shift in rare disease diagnosis by reimagining the tools, molecular technologies and analytical approaches used to identify the causal gene(s) and/or variant(s) underlying rare genetic disorders. This Notice of Funding Opportunity is intended to stimulate the development and testing of highly innovative experimental or computational approaches for rare disease diagnosis, that have the potential to make transformative improvements to the current state of the art.
The GREGoRi Innovation Projects (U01 Clinical Trial Optional) grant program is designed for researchers and organizations committed to transforming rare disease diagnosis. This NIH-funded initiative seeks to support the development and testing of highly innovative experimental or computational approaches that can identify the causal genes and variants underlying rare genetic disorders. Applicants should be focused on reimagining the tools, molecular technologies, and analytical approaches currently used in rare disease diagnosis, with the potential to make transformative improvements to the field. This grant is ideal for researchers, academic institutions, biotech companies, and clinical research organizations working at the intersection of genomics and rare disease diagnostics. Whether you're developing novel sequencing technologies, advanced computational algorithms, or innovative diagnostic platforms, GREGoRi Innovation Projects provides the funding and support needed to accelerate your work from concept to testing. The program welcomes both domestic and international organizations, including foreign components of U.S.-based entities, making it a truly global opportunity for rare disease research innovation. If you're ready to revolutionize how rare diseases are diagnosed and help patients receive faster, more accurate diagnoses, this grant program offers the resources and platform to make that vision a reality.
Funding Facts
● Applications openDeadline
October 30, 2026
Award Amount
$3 - $500K
Who can apply
Last verified July 5, 2026 · Source: Grants.gov
Grant Details
Grant Amount
$3 - $500K
Deadline
2026-10-30
Grant Type
federal
Application Cycle
Annual cycle with deadline October 30, 2026
Best For
Researchers, academic institutions, biotech companies, and clinical organizations developing innovative approaches to rare disease diagnosis and genomic research
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Frequently Asked Questions
Who is eligible for GREGoRi Innovation Projects (U01 Clinical Trial Optional)?
Eligible applicants include U.S. domestic organizations and international entities. Non-domestic (non-U.S.) organizations are eligible to apply, and non-domestic components of U.S. organizations are also welcome. Foreign components as defined in the NIH Grants Policy Statement are allowed. For comprehensive eligibility requirements, refer to Section III. Eligibility Information in the official Notice of Funding Opportunity (NOFO) on the NIH website.
How much funding does GREGoRi Innovation Projects (U01 Clinical Trial Optional) provide?
Funding ranges from $3 to $500,000. The specific amount awarded depends on the scope and innovation level of your proposed project. Check the official NOFO for detailed budget guidelines and funding cycles.
How do I apply for GREGoRi Innovation Projects (U01 Clinical Trial Optional)?
Applications are submitted through the NIH grants system. Visit the official NIH Grants website and search for the GREGoRi Innovation Projects Notice of Funding Opportunity (NOFO) for detailed application instructions, required forms, submission deadlines, and specific application guidelines. The next application deadline is October 30, 2026.
What can GREGoRi Innovation Projects (U01 Clinical Trial Optional) funding be used for?
Funding supports the development and testing of innovative experimental or computational approaches for rare disease diagnosis. This includes research aimed at identifying causal genes and/or variants underlying rare genetic disorders, developing new molecular technologies, creating advanced analytical approaches, and pursuing projects with the potential to transform the current state of rare disease diagnostics. The program is flexible regarding clinical trial inclusion, making it suitable for both pre-clinical and clinical research phases.
Last updated: July 5, 2026