GREGoRi Technology Integration Center (U01, Clinical Trials Optional)
About
The Genomics Research to Elucidate the Genetics of Rare Diseases: innovation (GREGoRi) initiative seeks to accelerate a paradigm shift in rare disease diagnosis by reimagining the tools, molecular technologies and analytical approaches used to identify the causal gene(s) and/or variant(s) underlying rare genetic disorders. The purpose of this Notice of Funding Opportunity is to establish the GREGoRi Technology Integration Center, which will enable the development of standards and best practices for applying new and emerging molecular methods in rare disease diagnosis. A major deliverable of the Center will be a multidimensional dataset that can be used for the development and benchmarking of novel tools and strategies that facilitate rare disease diagnosis.
The GREGoRi Technology Integration Center (U01, Clinical Trials Optional) is a nationwide funding opportunity designed for research institutions and organizations committed to advancing rare disease diagnosis through innovative molecular technologies and analytical approaches. This grant supports the establishment of a Technology Integration Center that will develop standards, best practices, and multidimensional datasets for applying emerging molecular methods in rare genetic disorder diagnosis. Funding of up to $2,250,000 is available to organizations that can contribute expertise in genomics, rare disease research, and technology integration. Applicants should be prepared to deliver benchmarking tools and strategies that facilitate rare disease diagnosis and contribute to a paradigm shift in how causal genes and variants are identified. This opportunity is ideal for academic medical centers, research hospitals, and biotechnology organizations with demonstrated capability in rare disease genomics research and a commitment to establishing industry standards. The initiative emphasizes innovation and collaboration, making it particularly valuable for institutions positioned to influence diagnostic practices nationally. Researchers and administrators should review the complete Notice of Funding Opportunity (NOFO) to understand specific eligibility requirements and application procedures before submitting proposals.
Funding Facts
● Applications openDeadline
October 30, 2026
Award Amount
Up to $2.3M
Who can apply
Last verified July 5, 2026 · Source: Grants.gov
Grant Details
Grant Amount
Up to $2.3M
Deadline
2026-10-30
Grant Type
federal
Application Cycle
Annual deadline (October 30, 2026)
Best For
Academic institutions, research hospitals, and biotechnology organizations focused on rare disease genomics and diagnostic innovation
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Frequently Asked Questions
Who is eligible for GREGoRi Technology Integration Center (U01, Clinical Trials Optional)?
U.S.-based organizations and institutions are eligible to apply. Foreign organizations and non-domestic components of U.S. organizations are not eligible; however, foreign components as defined in the NIH Grants Policy Statement are allowed as part of U.S. organization applications. For complete eligibility details, including institutional requirements and research capacity criteria, refer to Section III. Eligibility Information in the official Notice of Funding Opportunity (NOFO).
How much funding does GREGoRi Technology Integration Center (U01, Clinical Trials Optional) provide?
Up to $2,250,000 is available for this grant program. The exact funding amount for individual awards may vary based on the scope of proposed work and project requirements. Consult the official NOFO for details on budget guidelines and cost-sharing requirements.
How do I apply for GREGoRi Technology Integration Center (U01, Clinical Trials Optional)?
Applications are submitted through the standard NIH grants process. Interested applicants should review the complete Notice of Funding Opportunity (NOFO) for specific submission requirements, formatting guidelines, and required documentation. The application deadline is October 30, 2026. Visit the official NIH Grants website or the funding opportunity announcement page for detailed instructions, application portals, and technical support.
What can GREGoRi Technology Integration Center (U01, Clinical Trials Optional) funding be used for?
Funding supports the development and establishment of a Technology Integration Center focused on rare disease diagnosis. Primary uses include developing standards and best practices for applying new and emerging molecular methods, creating multidimensional datasets for benchmarking novel diagnostic tools and strategies, and advancing analytical approaches to identify causal genes and variants in rare genetic disorders. Clinical trials are optional components of proposed projects.
Last updated: July 5, 2026