HEAL Initiative: Translating Addiction Epidemiology, Prevention, Treatment, and Recovery Research into Practice (R61/R33 - Clinical Trial Optional)
About
The goal of this notice of funding opportunity (NOFO) is to address the opioid crisis and/or overdose events by supporting action-oriented research, accelerating the translation of addiction epidemiology, prevention, treatment services, and recovery research to practice. Proposed studies may target the individual, provider, organizational, community, or system level. This initiative prioritizes replicable and scalable approaches for accelerating the routine use of effective, evidence-based prevention, treatment and recovery interventions and services. The translation of research to practice and research relevant to chronic pain comorbid with substance use is also a priority. Research may deploy a variety of methods and approaches, including but not limited to identifying and characterizing malleable factors, developing and testing interventions and implementation strategies, deploying and testing collaborative data science approaches, and/or developing and testing approaches that integrate the collaboration of researchers and decision-makers at any levels (e. g., clinical-, health system-, public health- or policy-level).
The HEAL Initiative: Translating Addiction Epidemiology, Prevention, Treatment, and Recovery Research into Practice (R61/R33 - Clinical Trial Optional) is a federal grant program designed to combat the opioid crisis and reduce overdose events through action-oriented research. This program supports researchers, institutions, and organizations working to translate addiction research into real-world practice across multiple intervention levels—from individual and provider settings to organizational, community, and system-wide approaches. The initiative prioritizes replicable and scalable solutions that accelerate the adoption of evidence-based prevention, treatment, and recovery interventions. Researchers can employ various methodologies, including identifying malleable factors, developing and testing interventions, deploying collaborative data science approaches, and integrating researcher-decision-maker partnerships. A key focus area is research addressing chronic pain comorbid with substance use disorder. This grant is ideal for research institutions, academic medical centers, public health organizations, and healthcare systems committed to translating addiction science into practical, sustainable solutions that improve public health outcomes nationwide.
Funding Facts
● Applications openDeadline
February 9, 2029
Who can apply
Last verified July 5, 2026 · Source: Grants.gov
Grant Details
Funding Range
Varies by grant cycle
Deadline
2029-02-09
Grant Type
federal
Application Cycle
Annual with deadline February 9, 2029
Best For
Research institutions, academic medical centers, universities, public health organizations, and healthcare systems focused on translating addiction research into evidence-based practice
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Frequently Asked Questions
Who is eligible for HEAL Initiative: Translating Addiction Epidemiology, Prevention, Treatment, and Recovery Research into Practice (R61/R33 - Clinical Trial Optional)?
U.S. domestic entities and organizations are eligible. Non-domestic (non-U.S.) organizations cannot apply as primary applicants, and non-domestic components of U.S. organizations are ineligible. However, foreign components as defined in the NIH Grants Policy Statement are permitted. For complete eligibility requirements, including institutional classifications and research experience criteria, refer to Section III of the official Notice of Funding Opportunity (NOFO).
How much funding does HEAL Initiative: Translating Addiction Epidemiology, Prevention, Treatment, and Recovery Research into Practice (R61/R33 - Clinical Trial Optional) provide?
Specific funding amounts are not listed in the current information available. Funding amounts typically vary by grant cycle and project scope. Contact the National Institutes of Health (NIH) directly or visit the official NOFO webpage for current funding levels and budget details for this two-stage (R61/R33) grant mechanism.
How do I apply for HEAL Initiative: Translating Addiction Epidemiology, Prevention, Treatment, and Recovery Research into Practice (R61/R33 - Clinical Trial Optional)?
Applications are submitted through the NIH grants system. This is a two-stage (R61/R33) grant mechanism, meaning projects progress through an exploratory/feasibility stage (R61) before advancing to a full research and implementation stage (R33). The application deadline is February 9, 2029. Complete application instructions, required forms, and submission guidelines are available on the official NIH NOFO webpage. Review the NOFO carefully for specific submission requirements, timeline milestones, and evaluation criteria.
What can HEAL Initiative: Translating Addiction Epidemiology, Prevention, Treatment, and Recovery Research into Practice (R61/R33 - Clinical Trial Optional) funding be used for?
Funding supports action-oriented research that translates addiction epidemiology, prevention, treatment services, and recovery research into practice. Eligible research includes identifying and characterizing malleable factors, developing and testing interventions and implementation strategies, deploying collaborative data science approaches, and developing approaches that integrate researcher-decision-maker partnerships at clinical, health system, public health, or policy levels. Research addressing chronic pain comorbid with substance use disorder is also a priority. Clinical trials are optional. Proposed studies may target intervention at individual, provider, organizational, community, or system levels.
Last updated: July 5, 2026