Limited Competition for the Adolescent Brain Cognitive Development -Extended (ABCD-E) Study-Research Project Sites (U01 Clinical Trial Not Allowed)
About
This is a notice of funding opportunity (NOFO) for a Limited Competition that will invite applications from eligible organizations to apply. Please see Section III. Eligibility for additional information. In accordance with the National Institutes of Health (NIH) standard peer-review processes, the applications will be peer-reviewed, and only meritorious applications will be considered for funding. Only current award recipients will be eligible to apply. This NOFO seeks linked collaborative U01 applications to renew the current Adolescent Brain Cognitive Development (ABCD) Research Project Sites to extend study visits into young adulthood. This renewal, called Adolescent Brain Cognitive Development – Extended (ABCD-E) study, is critical to be able to follow these youth into emerging adulthood, when many of the outcomes of interest (e. g., substance use disorders, mental health disorders, chronic diseases, and other health conditions) will manifest. The structure of the ABCD-E study Consortium shall consist of three highly integrated components: (1) a set of linked Research Project Sites, (2) a single central Data Analysis, Informatics, and Resource Center, and (3) a single overall Coordinating Center. As such, this NOFO runs in parallel with a companion NOFO that solicits applications for two centers (RFA-DA-27-003). It is expected that investigators, upon funding, will work jointly with NIH scientific staff to assist, guide, coordinate, or participate in project activities.
The Limited Competition for the Adolescent Brain Cognitive Development -Extended (ABCD-E) Study-Research Project Sites is a National Institutes of Health (NIH) funding opportunity designed exclusively for organizations currently funded through the original ABCD initiative. This program supports research sites that will extend longitudinal study visits with participants into young adulthood, a critical period when many health outcomes—including substance use disorders, mental health disorders, and chronic diseases—typically manifest. The ABCD-E study represents a significant investment in understanding adolescent brain development and its long-term health implications. Research organizations and institutions with existing ABCD funding should apply to continue their vital work as linked collaborative research project sites. This renewal funding enables investigators to follow cohorts longitudinally, generating essential data on developmental trajectories and health outcomes. The study operates within an integrated consortium structure including research project sites, a central data analysis center, and a coordinating center. Researchers will collaborate directly with NIH scientific staff throughout the project period, ensuring alignment with national research priorities and maximizing the scientific impact of this groundbreaking longitudinal study.
Funding Facts
● Applications openDeadline
July 9, 2026
Who can apply
Last verified July 5, 2026 · Source: Grants.gov
Grant Details
Funding Range
Varies by cycle; contact NIH for specific amounts
Deadline
2026-07-09
Grant Type
federal
Application Cycle
Limited Competition (Invitation-only for eligible current awardees)
Best For
Current ABCD research project site organizations, research institutions, academic medical centers
Eligibility
Only organizations funded through RFA-DA-20-002 are eligible to apply. Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign comp
Frequently Asked Questions
Who is eligible for Limited Competition for the Adolescent Brain Cognitive Development -Extended (ABCD-E) Study-Research Project Sites (U01 Clinical Trial Not Allowed)?
Only organizations that are current award recipients funded through RFA-DA-20-002 are eligible to apply. Non-domestic (non-U.S.) entities and foreign components of U.S. organizations are not eligible. For complete eligibility requirements, refer to Section III of the official Notice of Funding Opportunity (NOFO) or contact the NIH directly.
How much funding does Limited Competition for the Adolescent Brain Cognitive Development -Extended (ABCD-E) Study-Research Project Sites (U01 Clinical Trial Not Allowed) provide?
Specific funding amounts vary and are not listed in the publicly available summary. Contact the NIH Division of Epidemiology, Services and Prevention Research or review the complete NOFO for detailed budget information and funding ranges for research project sites.
How do I apply for Limited Competition for the Adolescent Brain Cognitive Development -Extended (ABCD-E) Study-Research Project Sites (U01 Clinical Trial Not Allowed)?
Applications must be submitted through the NIH standard application process for U01 grants. Eligible organizations should review the complete NOFO, consult with their grants management office, and submit linked collaborative applications in accordance with NIH peer-review procedures. Visit the NIH grants website or the official NOFO announcement for detailed submission instructions and deadlines.
What can Limited Competition for the Adolescent Brain Cognitive Development -Extended (ABCD-E) Study-Research Project Sites (U01 Clinical Trial Not Allowed) funding be used for?
Funding supports renewal and extension of research project site activities to follow ABCD study participants into young adulthood. This includes study visits, data collection, participant retention, and research infrastructure necessary to examine developmental outcomes such as substance use disorders, mental health conditions, and chronic diseases. Sites function as part of an integrated consortium with centralized data analysis and coordination components.
Last updated: July 5, 2026