NIAID Investigator Initiated Program Project Applications (P01 Clinical Trial Not Allowed)
About
This notice of funding opportunity (NOFO) invites submission of investigator-initiated Program Project (P01) applications. The proposed Programs should address scientific areas relevant to the NIAID mission including: biology and pathogenesis of infectious microbes, including HIV; host-microbe interactions; mechanisms regulating immune system development and function across the lifespan, and in response to infectious pathogens; immune dysfunction resulting in allergy, asthma, autoimmunity, immunodeficiency, or transplant rejection; and translational research to develop vaccines, therapeutics, and diagnostics to prevent and treat infectious and immune-mediated diseases. Each application submitted to this NOFO must include at least two related, synergistic Research Projects that share a common central theme, focus, and/or overall objective; and an Administrative Core. An application may include Scientific Core(s), if needed for the proposed research.
The NIAID Investigator Initiated Program Project Applications (P01 Clinical Trial Not Allowed) is a federal funding opportunity designed for research institutions and investigators conducting advanced research aligned with the National Institute of Allergy and Infectious Diseases mission. This program supports investigator-initiated Program Project (P01) applications that address critical scientific areas including the biology and pathogenesis of infectious microbes, host-microbe interactions, immune system development and function, immune dysfunction conditions, and translational research for vaccines, therapeutics, and diagnostics. Eligible applicants must submit applications with at least two related, synergistic Research Projects sharing a common central theme, along with an Administrative Core and optional Scientific Core(s). This funding mechanism is ideal for research teams seeking to conduct coordinated, multi-project investigations into infectious and immune-mediated diseases. Researchers focused on advancing knowledge in immunology, microbiology, and translational medicine should consider applying. The program specifically excludes clinical trial components, making it suitable for basic science and translational research without direct patient intervention studies. Applicants must be U.S.-based entities; foreign organizations and non-domestic components of U.S. organizations are not eligible, though foreign components within approved structures are permitted. For complete eligibility requirements and application details, consult the official Notice of Funding Opportunity (NOFO) on the NIH website.
Funding Facts
● Applications openDeadline
May 25, 2029
Who can apply
Last verified July 5, 2026 · Source: Grants.gov
Grant Details
Funding Range
Varies by cycle
Deadline
2029-05-25
Grant Type
federal
Application Cycle
Annual (Deadline: May 25, 2029)
Best For
Research institutions and investigator teams conducting multi-project research in infectious diseases, immunology, and translational medicine
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Frequently Asked Questions
Who is eligible for NIAID Investigator Initiated Program Project Applications (P01 Clinical Trial Not Allowed)?
Eligible applicants must be domestic U.S. entities and organizations. Foreign organizations and non-domestic components of U.S. organizations are not eligible to apply. However, foreign components within approved structures may be included. For detailed eligibility information, including specific organizational requirements and principal investigator qualifications, refer to Section III of the official NOFO or visit the NIH grants website.
How much funding does NIAID Investigator Initiated Program Project Applications (P01 Clinical Trial Not Allowed) provide?
Specific funding amounts vary and are not specified in this summary. Award amounts depend on the scope and nature of the proposed research projects. Contact NIAID directly or consult the official NOFO for information on typical grant ranges and current funding availability for this application cycle.
How do I apply for NIAID Investigator Initiated Program Project Applications (P01 Clinical Trial Not Allowed)?
Applications must be submitted through the NIH grants portal. Each application must include at least two related, synergistic Research Projects that share a common central theme, plus an Administrative Core and any necessary Scientific Core(s). The deadline for this funding cycle is May 25, 2029. For detailed submission instructions, formatting requirements, and technical guidance, visit the official NOFO on the NIH website and review the NIH Grants Policy Statement.
What can NIAID Investigator Initiated Program Project Applications (P01 Clinical Trial Not Allowed) funding be used for?
Funding supports investigator-initiated Program Projects addressing NIAID mission areas, including: biology and pathogenesis of infectious microbes and HIV; host-microbe interactions; immune system development and function; immune dysfunction conditions such as allergy, asthma, autoimmunity, immunodeficiency, and transplant rejection; and translational research developing vaccines, therapeutics, and diagnostics for infectious and immune-mediated diseases. Clinical trial components are not permitted under this NOFO.
Last updated: July 5, 2026