NIH and CDC Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Required)
About
NIH and CDC Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Required) is a federal funding opportunity from National Institutes of Health. This forecasted grant opportunity (FOR-OD-26-002) is available nationwide for eligible applicants.
The NIH and CDC Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Required) is a federal funding opportunity designed specifically for small businesses developing innovative solutions in health and biomedical research. This grant program supports companies conducting research and development that addresses public health priorities identified by the National Institutes of Health and Centers for Disease Control and Prevention. The R43/R44 mechanism is structured in two phases, allowing businesses to establish feasibility in Phase I before scaling to full development in Phase II. A key requirement of this grant is the inclusion of a clinical trial component, making it ideal for small businesses creating diagnostic tools, medical devices, therapeutics, or public health interventions that require human testing. Entrepreneurs and small business owners in the biotech, medical device, diagnostics, and health IT sectors should apply if their innovations address unmet public health needs. This program provides not only capital but also validation and credibility from leading federal health agencies, positioning your company for future success, partnerships, and commercialization. For current funding amounts, specific deadlines, and detailed eligibility requirements, visit the official NIH grant announcement.
Grant Details
Funding Range
Varies by phase and research scope
Grant Type
Federal
Application Cycle
Forecasted opportunity - consult official announcement for specific deadlines
Best For
Small businesses developing health innovations, biotech startups, medical device companies, diagnostics firms, and health IT entrepreneurs with research requiring human clinical trials
Frequently Asked Questions
Who is eligible for NIH and CDC Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Required)?
Eligibility is limited to small businesses meeting the Small Business Administration's size standards. For specific eligibility criteria, including ownership requirements, business structure, and other qualifications, consult the official NIH grant announcement (FOR-OD-26-002) on grants.nih.gov or contact your local Small Business Development Center.
How much funding does NIH and CDC Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Required) provide?
Funding amounts vary by phase and research scope. Phase I and Phase II grants have different budget ranges. For specific funding levels for the current cycle, refer to the official grant announcement on the NIH website.
How do I apply for NIH and CDC Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Required)?
Applications are submitted through Grants.gov using the NIH SBIR grant mechanism. You'll need a DUNS number, SAM.gov registration, and an eRA Commons account. Detailed submission instructions and forms are available on the official NIH SBIR/STTR website. Review the specific solicitation (FOR-OD-26-002) for application deadlines and requirements.
What can NIH and CDC Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Required) funding be used for?
Funding supports research and development activities that advance innovations in health and biomedical science. Because a clinical trial is required, projects must include human testing components. Allowable uses typically include personnel, equipment, supplies, and clinical trial costs. For a complete list of allowable and unallowable expenses, consult the NIH Grants Policy Statement and your specific grant announcement.
Last updated: March 1, 2026