NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)
About
The Small Business Technology Transfer (STTR) grant program helps United States small business concerns (SBCs) that partner with a nonprofit research institution bring scientific innovations to the marketplace. The STTR program supports feasibility studies to later stage research and development (R&D) needed to develop a commercial product.
The NIH Small Business Technology Transfer Grant (STTR) Program, specifically the Parent STTR (R41/R42) track with clinical trial optional component, is designed for U.S. small business concerns that partner with nonprofit research institutions to commercialize scientific innovations. This grant program supports small businesses in advancing their technology from feasibility studies through later-stage research and development needed to bring commercial products to market. The STTR program is ideal for entrepreneurs and small business owners who have developed promising technologies but need resources to validate their approach, conduct proof-of-concept research, and prepare their innovation for commercialization. By partnering with academic research institutions, small businesses gain access to scientific expertise while maintaining ownership and commercialization rights. This grant is particularly valuable for companies in biotech, medical devices, pharmaceuticals, and other technology-intensive sectors seeking federal funding without giving up equity. The optional clinical trial component allows eligible applicants to include human subject research in their project scope. Small businesses should apply if they have proprietary technology, a strong research partnership, and a clear path to market commercialization. The program combines the resources of both private sector innovation and academic research excellence to accelerate technology transfer and economic impact.
Funding Facts
● Applications openDeadline
April 5, 2027
Who can apply
Last verified July 5, 2026 · Source: Grants.gov
Grant Details
Funding Range
Varies by phase and funding cycle
Deadline
2027-04-05
Grant Type
federal
Application Cycle
Annual (Deadline: April 5, 2027)
Best For
U.S. small businesses partnering with nonprofit research institutions to commercialize scientific innovations
Eligibility
Only United States small business concerns (SBCs), as defined by the Small Business Administration (SBA)(sbir.gov/apply) are eligible to submit applications for this opportunity.Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligib
Frequently Asked Questions
Who is eligible for NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)?
Only United States small business concerns (SBCs), as defined by the Small Business Administration (SBA), are eligible to submit applications. The small business must partner with a nonprofit research institution. Foreign organizations and non-U.S. entities are not eligible. For complete eligibility requirements, including specific SBC definitions and partnership criteria, refer to Section III of the Notice of Funding Opportunity (NOFO) or visit sbir.gov/apply and the official NIH STTR program website.
How much funding does NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional) provide?
The specific funding amount is not specified in the standard program description and varies by funding cycle and project phase. Phase I (R41) and Phase II (R42) grants have different award levels. For current funding amounts and budget limits, applicants should consult the most recent Notice of Funding Opportunity (NOFO) and the official NIH STTR program website, as amounts may change annually.
How do I apply for NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)?
Applications are submitted through the NIH electronic submission system (eRA Commons/grants.nih.gov). Small businesses must partner with a nonprofit research institution and submit a collaborative proposal. The application process requires detailed project descriptions, budget justifications, commercialization plans, and evidence of the small business-research institution partnership. For step-by-step application instructions, deadlines, and submission requirements, visit grants.nih.gov or the NIH STTR program website. The next application deadline is April 5, 2027.
What can NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional) funding be used for?
STTR grant funding supports feasibility studies and later-stage research and development (R&D) needed to develop commercial products. Funds can be used for scientific and technical research conducted in partnership with the nonprofit research institution, proof-of-concept studies, technology validation, and development activities that move the innovation toward commercialization. The optional clinical trial component allows inclusion of human subject research. Specific allowable costs and restrictions are detailed in the NIH Grants Policy Statement and the relevant NOFO.
Last updated: July 5, 2026