Research Grants in Clinical Informatics (R01 Clinical Trial Optional)
About
The National Library of Medicine (NLM) seeks applications for innovative research in clinical informatics. The overarching goal of this forthcoming program is to catalyze the development and advancement of novel informatics methodologies that empower clinicians, patients, and the broader public to better understand, manage, and improve health and health care delivery. This NOFO will support research focused on the design, implementation, and evaluation of clinical informatics tools and methods that enable data-driven discovery, promote evidence-based decision-making, and support personalized and precision health care. Emphasis will be placed on domain-independent, scalable, and reusable/reproducible approaches for the discovery, analysis, organization, and management of health-related digital objects—including electronic health records (EHRs), clinical notes, imaging data, and patient-generated data. The aim is to transform raw and heterogeneous health data into actionable knowledge, to develop innovative tools, and to implement practical applications that can be generalized across multiple clinical settings and populations. Projects should demonstrate the potential to accelerate scientific insights, improve clinical workflows, and ultimately lead to improved health outcomes.
The Research Grants in Clinical Informatics (R01 Clinical Trial Optional) program, offered by the National Library of Medicine, is designed for researchers and innovators developing cutting-edge informatics solutions that transform healthcare delivery. This grant funds the creation and evaluation of novel clinical informatics methodologies, tools, and applications that empower clinicians, patients, and the public to make better health decisions. The program supports research focused on designing, implementing, and evaluating informatics systems that work with electronic health records, clinical notes, imaging data, and patient-generated information. Applicants should demonstrate how their projects can scale across multiple clinical settings, improve clinical workflows, and ultimately lead to better health outcomes. The grant emphasizes domain-independent, reusable approaches that convert raw, heterogeneous health data into actionable knowledge. Organizations and researchers working on evidence-based decision-making tools, personalized medicine platforms, and data-driven healthcare innovations should consider applying. International collaborations and non-U.S. organizations are welcome to submit applications, making this a globally accessible funding opportunity for advancing clinical informatics research.
Funding Facts
● Applications openDeadline
March 5, 2029
Award Amount
Up to $250K
Who can apply
Last verified July 5, 2026 · Source: Grants.gov
Grant Details
Grant Amount
Up to $250K
Deadline
2029-03-05
Grant Type
federal
Application Cycle
Annual (Next deadline: March 5, 2029)
Best For
Researchers and organizations developing clinical informatics tools, EHR solutions, evidence-based decision systems, and data-driven healthcare innovations
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no l
Frequently Asked Questions
Who is eligible for Research Grants in Clinical Informatics (R01 Clinical Trial Optional)?
Eligibility includes domestic U.S. organizations and foreign organizations. Non-domestic components of U.S. organizations and foreign components as defined in the NIH Grants Policy Statement are eligible to apply. For complete eligibility requirements, including institutional qualifications and researcher credentials, refer to Section III of the Notice of Funding Opportunity (NOFO) on the official NIH/NLM website.
How much funding does Research Grants in Clinical Informatics (R01 Clinical Trial Optional) provide?
Funding ranges from up to $250,000. The exact amount awarded may vary based on project scope, research complexity, and annual funding cycles. Contact the National Library of Medicine directly or review the current NOFO for specific funding details for the upcoming cycle.
How do I apply for Research Grants in Clinical Informatics (R01 Clinical Trial Optional)?
Applications are submitted through the NIH electronic submission system, typically via Grants.gov. Applicants should review the current NOFO for specific application requirements, submission deadlines, and required documentation. The next deadline is March 5, 2029. Visit the National Library of Medicine website or NIH Grants portal for detailed instructions, application forms, and technical support.
What can Research Grants in Clinical Informatics (R01 Clinical Trial Optional) funding be used for?
Funding supports research focused on designing, implementing, and evaluating clinical informatics tools and methodologies. Eligible projects include development of systems for analyzing electronic health records, clinical notes, imaging data, and patient-generated information; creation of data management and organization solutions; development of evidence-based decision-making tools; and implementation of personalized or precision healthcare applications. Projects must demonstrate scalability and reproducibility across clinical settings.
Last updated: July 5, 2026