Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)
About
The Office of Research Infrastructure Programs (ORIP) encourages grant applications aimed at developing, characterizing, or improving research models of human health and diseases; developing biology based new approach methodologies (NAMs) applicable to human health and diseases; or improving access to information about or generated from the use of models of human disease. The models, including NAMs, and related biological materials developed must be broadly applicable to the scientific interests of two or more NIH Institutes or Centers (ICs) and must evaluate diseases and processes that impact multiple organ systems in order to align with the ORIP"s NIH-wide mission and programs. Applications must describe the need for and the potential impact of the proposed resources on the research community across a range of scientific disciplines supported by multiple NIH ICs. Applications to develop models that relate strictly to a specific disease or a select area of research or that do not have a broad impact on the NIH-wide research community will not be accepted. Projects that predominantly address the research interests of one NIH IC but are only peripherally related to the research interests of other ICs will also not be accepted, if submitted in response to this notice of funding opportunity (NOFO).
The Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed) grant is offered by the National Institutes of Health (NIH) Office of Research Infrastructure Programs (ORIP) to support the development and improvement of research models and biological materials that advance understanding of human health and diseases. This grant program is designed for research institutions, universities, and organizations seeking to create broadly applicable resources that benefit the NIH-wide research community. Funded projects may develop disease models, new approach methodologies (NAMs), or improve access to information and materials derived from disease models. A critical requirement is that all developed models and resources must have application across multiple NIH Institutes or Centers and address diseases or biological processes affecting multiple organ systems. This ensures funding supports infrastructure that benefits diverse research disciplines rather than narrowly focused studies. Researchers should apply if they are developing innovative models or biological resources with cross-disciplinary relevance that will significantly impact the broader scientific community. Clinical trials are not permitted under this funding mechanism, keeping focus on model development and characterization rather than human subject research.
Funding Facts
● Applications openDeadline
September 28, 2028
Who can apply
Last verified July 5, 2026 · Source: Grants.gov
Grant Details
Funding Range
Varies by funding cycle
Deadline
2028-09-28
Grant Type
federal
Application Cycle
Annual (with deadline of September 28, 2028)
Best For
Research institutions, universities, and organizations developing broadly applicable disease models, biological materials, and research infrastructure benefiting multiple NIH research communities
Eligibility
Refer to Section III. Eligibility Information of the NOFO for additional information on eligibility.Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Frequently Asked Questions
Who is eligible for Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)?
U.S. domestic entities including research institutions, universities, and organizations are eligible. Foreign organizations and non-domestic components of U.S. organizations are not eligible. Foreign collaborations and foreign components as defined in the NIH Grants Policy Statement are not allowed. For detailed eligibility requirements, refer to Section III of the official Notice of Funding Opportunity (NOFO) on the NIH website.
How much funding does Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed) provide?
Specific funding amounts are not specified in the current program information. Funding varies by funding cycle and project scope. Contact the NIH Office of Research Infrastructure Programs or visit the official NOFO for current funding ranges and budget guidelines.
How do I apply for Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)?
Applications are submitted through the NIH electronic submission system (eRA Commons/grants.nih.gov). Applicants must prepare a research proposal demonstrating how their models or biological resources will have broad applicability across multiple NIH Institutes or Centers and impact multiple organ systems. For complete application instructions, deadlines, and submission procedures, visit the official NIH NOFO page and refer to NIH grants policies and guidelines.
What can Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed) funding be used for?
Funding supports development, characterization, or improvement of research models for human health and diseases; development of biology-based new approach methodologies (NAMs) applicable to human health and diseases; and improving access to information and materials generated from disease models. Projects must demonstrate broad applicability to multiple NIH research communities. Clinical trials are not permitted. Models must address multi-organ system impacts to align with ORIP's NIH-wide mission.
Last updated: July 5, 2026