SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional)
About
The Commercialization Readiness Pilot (CRP) program helps small business concerns (SBCs) move NIH-funded SBIR or STTR projects from late-stage development to commercialization. The CRP supports later-stage research and development (R&D) and/or technical assistance that Phase II and Phase IIB Strategic Breakthrough awards do not typically support. This includes: Independent replication or confirmation of key studiesIND- or IDE-enabling studiesClinical studiesManufacturing scale-up and related quality activitiesRegulatory and other specialized technical supportSBCs may subcontract (outsource) a significant amount of the work in a CRP to meet the project goals.
The SBIR/STTR Commercialization Readiness Pilot (CRP) Program is designed for small business concerns that have successfully completed NIH-funded SBIR or STTR Phase II or Phase IIB Strategic Breakthrough projects and are ready to transition from late-stage development into commercialization. This program fills a critical funding gap by supporting activities that earlier-phase grants typically cannot cover, including independent replication studies, IND or IDE-enabling research, clinical trials, manufacturing scale-up, quality assurance activities, and specialized regulatory and technical support. If your small business has developed an innovative medical, biotech, or health-related technology through NIH funding and needs resources to take it to market, the CRP Program is an essential opportunity. The program recognizes that the path from research to commercialization requires significant additional investment beyond traditional Phase II funding. Small businesses can also subcontract a substantial portion of work to specialized partners, allowing you to leverage external expertise while maintaining project leadership. This is a nationwide program open exclusively to U.S.-based small business concerns, making it a vital resource for American entrepreneurs in the life sciences and biomedical sectors ready to bring their innovations to market.
Funding Facts
● Applications openDeadline
April 5, 2029
Who can apply
Last verified July 5, 2026 · Source: Grants.gov
Grant Details
Funding Range
Varies by cycle
Deadline
2029-04-05
Grant Type
federal
Application Cycle
Deadline-based (Next deadline: April 5, 2029)
Best For
U.S. small business concerns with completed NIH SBIR/STTR Phase II or Phase IIB projects ready for commercialization
Eligibility
Only United States small business concerns (SBCs), as defined by the Small Business Administration (SBA)(sbir.gov/apply) are eligible to submit applications for this opportunity.Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligib
Frequently Asked Questions
Who is eligible for SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional)?
Only United States small business concerns (SBCs), as defined by the Small Business Administration (SBA), are eligible to apply. Your business must be SBA-certified and meet their size standards. Foreign organizations and non-domestic entities are not eligible. For detailed eligibility requirements and definitions, consult Section III of the official Funding Opportunity Announcement (NOFO) and visit sbir.gov/apply for SBA small business concern definitions.
How much funding does SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional) provide?
Specific funding amounts vary and are not listed in the current program information. Contact the National Institutes of Health (NIH) directly or review the official NOFO for current funding levels, as amounts may vary by fiscal year and program cycle.
How do I apply for SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional)?
Applications are submitted through the official NIH grants portal. Ensure your small business is SBA-certified before applying. Review the complete Funding Opportunity Announcement (NOFO) for submission guidelines, required documentation, and deadlines. Visit grants.nih.gov and sbir.gov for application instructions, eligibility verification, and technical support.
What can SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional) funding be used for?
CRP funding supports commercialization-focused activities including: independent replication or confirmation of key studies; IND (Investigational New Drug) or IDE (Investigational Device Exemption) enabling studies; clinical trials; manufacturing scale-up and quality assurance activities; and regulatory or other specialized technical support. You may also subcontract a significant portion of work to external partners to achieve project goals.
Last updated: July 5, 2026