Seed Instrumentation Support (SIS) Program (S10 Clinical Trial Not Allowed)
About
This Notice of Funding Opportunity (NOFO) aims to build new research capacity and develop a sustainable research program by supporting the purchase of a single commercially available biomedical research instrument currently unavailable in the institution. Instruments funded through this program must be shared among the users to create new research opportunities, enable reproducible data generation, encourage collaborative research and training, and strengthen long-term research capabilities. The minimum award is $50,000. While there is no limit on the total cost of the instrument, the maximum award is $400,000.
The Seed Instrumentation Support (SIS) Program is a federal funding opportunity designed for research institutions seeking to build new research capacity and establish sustainable research programs. This grant supports the purchase of a single commercially available biomedical research instrument that is not currently available at your institution. The program emphasizes collaborative research by requiring that funded instruments be shared among multiple users to create new research opportunities, enable reproducible data generation, and strengthen long-term research capabilities. With funding ranging from $50,000 to $400,000, the SIS Program is ideal for institutions looking to acquire specialized equipment that will accelerate research initiatives and facilitate training opportunities. Eligible U.S.-based organizations can leverage this funding to remove barriers to innovation and develop research infrastructure that supports multiple departments and research teams. The program specifically excludes clinical trial studies, making it perfect for basic and applied biomedical research institutions. By investing in shared research instruments, your institution can enhance collaborative research networks, improve data quality, and position itself for future research growth and competitiveness.
Funding Facts
● Applications openDeadline
July 1, 2028
Award Amount
$50K - $400K
Who can apply
Last verified July 5, 2026 · Source: Grants.gov
Grant Details
Grant Amount
$50K - $400K
Deadline
2028-07-01
Grant Type
federal
Application Cycle
Annual (Deadline: July 1, 2028)
Best For
U.S.-based research institutions seeking to build biomedical research capacity through shared instrumentation
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Frequently Asked Questions
Who is eligible for Seed Instrumentation Support (SIS) Program (S10 Clinical Trial Not Allowed)?
U.S.-based domestic organizations are eligible to apply. Non-domestic (non-U.S.) entities and foreign components of U.S. organizations are not eligible. For comprehensive eligibility requirements, refer to Section III. Eligibility Information in the official Notice of Funding Opportunity (NOFO) on the NIH website.
How much funding does Seed Instrumentation Support (SIS) Program (S10 Clinical Trial Not Allowed) provide?
The SIS Program provides awards ranging from a minimum of $50,000 to a maximum of $400,000. While there is no stated limit on the total cost of the instrument itself, funding awards are capped at $400,000. The specific amount awarded may vary based on your institution's needs and the cost of the requested instrument.
How do I apply for Seed Instrumentation Support (SIS) Program (S10 Clinical Trial Not Allowed)?
Applications are submitted through the NIH grants application system. The application deadline is July 1, 2028. Visit the official NIH website or the grants.nih.gov portal for detailed application instructions, required documentation, and submission procedures. Begin your application early to ensure all materials meet program requirements.
What can Seed Instrumentation Support (SIS) Program (S10 Clinical Trial Not Allowed) funding be used for?
Funding supports the purchase of a single commercially available biomedical research instrument that is not currently available at your institution. The instrument must be designed for shared use among multiple researchers to enable collaborative research, reproducible data generation, and training opportunities. Clinical trial studies are not eligible for support under this program.
Last updated: July 5, 2026