Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)
About
This Notice of Funding Opportunity (NOFO) announces the restructured Shared Instrumentation Grant (SIG) Program that consolidates three existing shared-use instrumentation programs, i. e., the Shared Instrumentation Grant program, the High-End Instrumentation Grant program, and the Basic Instrumentation Grant program. The NOFO invites applications from groups of NIH-supported investigators to purchase or upgrade a single state-of-the-art commercially available instrument or an integrated instrumentation system. The instruments purchased through the SIG Program are required to be optimally shared among the users to ensure efficient and cost-effective research operations, enable rigorous and reproducible measurements, and encourage collaborative research and benefit broad research communities at large. The minimum award is $300,000. There is no cap on the total cost of the instrument; however, the maximum award is $5,000,000. Cost sharing is required for premium instruments or special use instruments.
The Shared Instrumentation Grant (SIG) Program is a federal funding opportunity designed for groups of NIH-supported investigators seeking to purchase or upgrade state-of-the-art research instrumentation. This consolidated program brings together three previously separate NIH instrumentation initiatives, offering substantial funding from $300,000 to $5,000,000 for qualified applicants. The program prioritizes instruments and integrated systems that will be shared among multiple users, promoting collaborative research, ensuring cost-effective operations, and enabling rigorous, reproducible measurements across research communities. Researchers and institutional groups should apply if they need significant capital investment in cutting-edge equipment to advance their NIH-funded work. The program emphasizes optimal shared-use models that maximize research efficiency and broaden the impact of instrumentation investments. Cost sharing requirements apply to premium or specialized instruments. This is an excellent opportunity for research institutions and investigator groups to access funding for instruments that would otherwise be financially challenging to acquire independently, while strengthening collaborative research infrastructure.
Funding Facts
● Applications openDeadline
July 1, 2028
Award Amount
$300K - $5M
Who can apply
Last verified July 5, 2026 · Source: Grants.gov
Grant Details
Grant Amount
$300K - $5M
Deadline
2028-07-01
Grant Type
federal
Application Cycle
Annual (Deadline: July 1, 2028)
Best For
Groups of NIH-supported investigators, research institutions, academic medical centers seeking shared-use research instrumentation
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Frequently Asked Questions
Who is eligible for Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)?
The program invites applications from groups of NIH-supported investigators. Foreign organizations and non-domestic components of U.S. organizations are not eligible. Foreign components as defined in the NIH Grants Policy Statement are not allowed. For complete eligibility requirements and exceptions, refer to Section III of the official Notice of Funding Opportunity (NOFO) on the NIH website.
How much funding does Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed) provide?
The SIG Program provides awards ranging from a minimum of $300,000 to a maximum of $5,000,000. There is no cap on the total cost of the instrument itself, though the maximum award amount is $5,000,000. Cost sharing is required for premium instruments or special use instruments. Specific funding amounts depend on the instrument and institutional circumstances.
How do I apply for Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)?
Applications must follow the guidelines provided in the official Notice of Funding Opportunity (NOFO). The application deadline is July 1, 2028. Applicants should visit the NIH grants website to access the complete NOFO, submission instructions, and all technical requirements. Applications are submitted through the NIH electronic submission system in accordance with federal grant application procedures.
What can Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed) funding be used for?
Funding supports the purchase or upgrade of single state-of-the-art commercially available instruments or integrated instrumentation systems. The instruments must be optimally shared among multiple users to ensure efficient, cost-effective research operations and enable collaborative research. The grant emphasizes instruments that will be used across a broad research community rather than for single-investigator use. Clinical trial applications are not allowed under this specific program.
Last updated: July 5, 2026