The Genesis Mission: Transforming Science and Energy with AI
About
The DOE Office of Science (SC), Office of Critical Minerals and Energy Innovation (CMEI), Office of Environmental Management (EM), Office of Nuclear Energy (NE), Office of Electricity (OE), and Hydrocarbons and Geothermal Office (HGEO) hereby announce interest in receiving applications from interdisciplinary teams addressing the Genesis Mission National Science and Technology Challenges to accelerate scientific discovery and research and development (R&D) workflows using novel artificial intelligence (AI) models and frameworks. By achieving AI advantage, these teams will advance the DOE's mission and ensure America’s security and prosperity by addressing energy, environmental, and nuclear challenges through science and technology. Teams are encouraged to leverage the extensive scientific and data resources of the DOE/National Nuclear Security Administration (NNSA), the National Laboratories, U. S. industry, and academia. The resulting AI models and workflows, if successful, may be integrated into the American Science Cloud. DOE is soliciting new FY26 Phase I small team and Phase II large team applications in the following topic areas: advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy (see specific focus areas in Section III Program Descriptions). In addition, this RFA will remain available to allow the recipients of FY26 Phase I awards to ap.
The Genesis Mission: Transforming Science and Energy with AI is a prestigious federal grant program administered by the U.S. Department of Energy (DOE) designed for interdisciplinary teams ready to revolutionize scientific discovery and research through artificial intelligence. This program targets researchers, scientists, and innovators from the National Laboratories, academia, and U.S. industry who are tackling critical challenges in advanced manufacturing, biotechnology, critical materials, nuclear fission and fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy sectors. The Genesis Mission funds both small Phase I teams and large Phase II teams, providing substantial resources ranging from $500,000 to $16,000,000 to develop novel AI models and frameworks that accelerate R&D workflows. Successful projects may integrate into the American Science Cloud, amplifying impact across the scientific community. Entrepreneurs and research leaders should apply if they're developing cutting-edge AI solutions that advance DOE's mission to ensure America's energy security, environmental stewardship, and technological prosperity. This is an exceptional opportunity to access world-class scientific and data resources while contributing to transformative solutions in critical national priority areas.
Funding Facts
● Applications openDeadline
December 17, 2026
Award Amount
$500K - $16M
Who can apply
Last verified July 5, 2026 · Source: Grants.gov
Grant Details
Grant Amount
$500K - $16M
Deadline
2026-12-17
Grant Type
federal
Application Cycle
Annual (FY26 deadline December 17, 2026)
Best For
Interdisciplinary research teams from National Laboratories, academia, and U.S. industry addressing DOE science and energy challenges with artificial intelligence
Frequently Asked Questions
Who is eligible for The Genesis Mission: Transforming Science and Energy with AI?
The program encourages interdisciplinary teams from DOE National Laboratories, academia, U.S. industry, and combinations thereof. Teams should address Genesis Mission National Science and Technology Challenges with novel AI approaches. For detailed eligibility criteria, visit the official DOE announcement page, as specific requirements may vary by topic area and phase.
How much funding does The Genesis Mission: Transforming Science and Energy with AI provide?
Funding ranges from $500,000 to $16,000,000, with amounts varying based on project scope, phase (Phase I small teams or Phase II large teams), and topic area. Consult the official RFA documentation for specific funding levels by category.
How do I apply for The Genesis Mission: Transforming Science and Energy with AI?
Applications are submitted through the official DOE application portal. The program accepts FY26 Phase I and Phase II applications, with a deadline of December 17, 2026. Visit the DOE Office of Science website for the complete Request for Application (RFA), submission guidelines, and technical requirements. Phase I award recipients can transition to Phase II opportunities.
What can The Genesis Mission: Transforming Science and Energy with AI funding be used for?
Funding supports AI-driven research and development across nine focus areas: advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy. Projects should develop novel AI models and workflows that accelerate scientific discovery and R&D. Successful outcomes may be integrated into the American Science Cloud for broader scientific benefit.
Last updated: July 5, 2026