Validation Center for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U54 Clinical Trials Not Allowed)
About
The overarching goal of this notice of funding opportunity (NOFO) and its companion opportunities is to establish the Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Program to support development of innovative, reliable, cost-effective, and sustainable multimodal AI-based clinical decision support (CDS) tools. PRIMED-AI CDS tools are based on the integration of clinical imaging with other types of multimodal health data to enhance care for patients with a wide range of health conditions. The PRIMED-AI Program seeks to catalyze the adoption of AI-based CDS tools into clinical workflows to enable novel personalized medicine strategies that address significant health challenges. The purpose of this NOFO is to solicit applications for the creation of a Validation Center to serve as a dedicated hub for the comprehensive evaluation and characterization of AI-enabled, image-based, multimodal CDS tools developed by the PRIMED-AI Consortium, to ensure these tools are reliable, reproducible, and generalizable. The Validation Center will focus on verification, validation, interoperability, and uncertainty quantification to comprehensively characterize performance of the CDS tools developed by the program. The core functions of the Validation Center will involve the systematic validation of PRIMED-AI Consortium deliverables, including those emerging from award recipients under the Playbook, Data-to-Model Academic-Industrial Partnerships, and Model-to-Cli.
The Validation Center for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) grant supports the creation of a dedicated validation hub for AI-enabled clinical decision support (CDS) tools that integrate medical imaging with multimodal health data. This grant is designed for research institutions, academic medical centers, and organizations capable of establishing a comprehensive evaluation center that can verify, validate, assess interoperability, and quantify uncertainty in AI-based tools developed through the PRIMED-AI Consortium. The Validation Center will serve as a critical infrastructure resource, systematically characterizing the performance, reliability, reproducibility, and generalizability of AI tools designed to enhance personalized medicine strategies across various health conditions. Applicants should have expertise in AI validation methodologies, clinical imaging, health data integration, and the ability to work collaboratively with multiple PRIMED-AI award recipients. This opportunity is ideal for organizations seeking to advance the clinical adoption of AI-based decision support systems and establish themselves as leaders in AI validation and quality assurance. The program specifically excludes clinical trial components, focusing instead on the technical and analytical validation of existing and emerging AI tools to ensure they meet rigorous standards for clinical implementation.
Funding Facts
● Applications openDeadline
October 2, 2026
Award Amount
Up to $2M
Who can apply
Last verified July 5, 2026 · Source: Grants.gov
Grant Details
Grant Amount
Up to $2M
Deadline
2026-10-02
Grant Type
federal
Application Cycle
Annual
Best For
Research institutions, academic medical centers, and U.S.-based organizations with AI validation expertise and capacity to serve as a collaborative hub for the PRIMED-AI Consortium
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Frequently Asked Questions
Who is eligible for Validation Center for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U54 Clinical Trials Not Allowed)?
Domestic U.S. organizations are eligible to apply. Foreign organizations, non-domestic components of U.S. organizations, and foreign components as defined in the NIH Grants Policy Statement are not eligible. For complete eligibility requirements, including specific institutional qualifications and experience requirements, refer to Section III of the official Notice of Funding Opportunity (NOFO) on the NIH website.
How much funding does Validation Center for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U54 Clinical Trials Not Allowed) provide?
Funding is available up to $2,000,000. The actual award amount may vary based on the scope of the proposed validation center, institutional capacity, and evaluation criteria set by the funding agency. Applicants should consult the official NOFO for specific budget guidance and budget period information.
How do I apply for Validation Center for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U54 Clinical Trials Not Allowed)?
Applications must be submitted through the official NIH application system (Grants.gov or similar platform designated in the NOFO). Applicants should review the complete Notice of Funding Opportunity for detailed instructions, including required forms, documentation, project narrative guidelines, and submission deadlines. The application deadline is October 2, 2026. Visit the NIH website or the specific funding opportunity page for step-by-step application instructions and technical support.
What can Validation Center for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U54 Clinical Trials Not Allowed) funding be used for?
Funding supports the establishment and operation of a Validation Center focused on comprehensive evaluation of AI-enabled clinical decision support tools. This includes activities such as verification and validation of multimodal AI tools, interoperability testing, uncertainty quantification, performance characterization, and systematic evaluation of tools developed by PRIMED-AI Consortium members. The center will assess reliability, reproducibility, and generalizability of AI-based imaging and multimodal data integration tools. Note that clinical trial components are not permitted under this funding mechanism.
Last updated: July 5, 2026