How to Start a Business in Missouri

Your complete 2026 guide to business registration, state taxes, licenses, and key industries in Missouri.

Missouri offers entrepreneurs a business-friendly environment with straightforward registration processes and competitive tax advantages. Whether you're launching a startup or relocating an established business, understanding the state's requirements will help you navigate the process efficiently.

When establishing a business in Missouri, your first decision involves selecting an appropriate business structure. Missouri recognizes several entity types, including sole proprietorships, partnerships, limited liability companies (LLCs), and corporations. Sole proprietorships are the simplest form, requiring minimal paperwork but offering no personal liability protection. Partnerships allow two or more individuals to share ownership and management responsibilities. Limited liability companies provide a middle ground, offering liability protection while maintaining flexible tax treatment and management structures. Corporations, whether S-corps or C-corps, provide the strongest liability protection but involve more complex administrative requirements and taxation.

To formally establish your business entity in Missouri, you'll need to register with the Missouri Secretary of State. The specific filing requirements depend on your chosen structure. Sole proprietors may only need a business license from their local city or county, while LLCs, corporations, and partnerships require filing Articles of Organization or Incorporation with the Secretary of State. These filings involve submitting the appropriate documents along with applicable fees—check the current fee structure at the Missouri Secretary of State website, as fees may vary by entity type. Processing typically takes several business days to a few weeks depending on the filing method and current workload.

A critical requirement for most business entities is appointing a registered agent. This individual or business serves as your official point of contact for legal documents and regulatory correspondence. Your registered agent must maintain a physical address in Missouri and be available during business hours to receive important notices. Many small business owners designate themselves as registered agents, while others hire professional registered agent services for this purpose.

Regarding taxation, Missouri businesses should understand the state's tax obligations. Missouri imposes a state income tax on business profits, with individual and corporate rates varying based on your entity type and income level. The state also administers a sales tax that applies to most retail transactions, though certain goods and services may be exempt. Businesses collecting sales tax must obtain a sales tax permit from the Department of Revenue and remit collections according to state schedules.

Missouri offers some notable tax considerations for business owners. The state does not have a separate franchise tax on most business entities, which can provide savings compared to other states. Additionally, Missouri provides various tax credits and incentives for qualifying businesses in specific industries or economic development zones. Small business owners should consult with a tax professional to maximize available benefits and ensure compliance with state requirements.

Beyond entity registration and tax obligations, most Missouri businesses must obtain appropriate licenses and permits. A general business license from your city or county government is typically required before operating. However, the specific licenses you need depend heavily on your industry. Healthcare providers, contractors, real estate agents, and other regulated professions must obtain professional licenses from state licensing boards. Food service businesses require health permits, and certain industries may need environmental permits or other specialized authorization.

Licensing requirements vary significantly between local jurisdictions and state agencies. While some municipalities handle general business licensing, the state manages professional licensing through various boards and commissions. Researching your specific industry's requirements before launching is essential to avoid compliance issues.

Missouri's economy features several prominent industries that drive business growth. The state has strong manufacturing, healthcare, and financial services sectors, particularly in major cities like St. Louis and Kansas City. Missouri's central location makes it attractive for logistics and distribution companies. The state also supports a growing technology sector, with increasing startup activity in Columbia and the Kansas City metropolitan area. Agricultural and agribusiness operations remain significant throughout the state, and Missouri's natural resources support forestry and mining sectors.

The state actively supports business development through various programs and incentives. Missouri offers tax credits for job creation, research and development activities, and investments in economically distressed areas. The state's strategic location, reasonable cost of living, and educated workforce make it competitive for companies in diverse industries.

Successfully starting a business in Missouri requires attention to entity formation, tax registration, and obtaining necessary licenses. By understanding these requirements upfront and utilizing available resources, you'll establish a solid foundation for your business venture in Missouri.

Frequently Asked Questions

What are the requirements for registering a business in Missouri?
Missouri requires you to register your business name with the Secretary of State if you're operating under a name different from your legal name. For LLCs and corporations, you'll need to file Articles of Organization or Articles of Incorporation with the Missouri Secretary of State website. You'll also need an Employer Identification Number (EIN) from the IRS if you have employees or operate as a partnership or corporation.
Does Missouri have a state income tax for businesses?
Yes, Missouri has a corporate income tax that applies to C corporations and a personal income tax that applies to sole proprietors and pass-through entities like S corporations and LLCs. The state also requires businesses to register for Missouri state income tax withholding if they have employees. Check the Missouri Department of Revenue website for current tax rates and filing deadlines.
Are there any startup incentives or programs available in Missouri?
Missouri offers various economic development programs and tax credits for qualifying businesses, particularly in designated areas or industries. The Missouri Department of Economic Development provides information on programs like the Quality Jobs Program and enterprise zone benefits. Small businesses may also benefit from state-sponsored training and workforce development resources.
How long does it typically take to start a business in Missouri?
Filing your business formation documents with the Missouri Secretary of State typically takes 1-5 business days for processing, though you can expedite this for an additional fee. However, the overall timeline depends on your business type—you may also need local licenses, permits, or health department approvals, which can add several days to weeks. It's best to check with your local county clerk and city/county health department for specific timelines in your area.
What licenses or permits do I need to start a business in Missouri?
Most Missouri businesses need a general business license from their city or county, which you typically obtain through your local government office. Depending on your industry, you may need additional permits—for example, food service businesses need health permits, while contractors need licensing through the Missouri Department of Commerce. Check with your specific city, county, and industry to determine all required licenses and permits.

Find Resources in Missouri

Explore coworking spaces, grants, accelerators, and SBA resources in these Missouri cities:

Ready to Start Your Business?

Get personalized guidance, a custom business plan, and matched resources for your specific idea and location.

Start Building Your Plan